Acute disseminated encephalomyelitis Autoimmunity diseases Human papilloma virus vaccine Juvenile idiopathic arthritis Multiple sclerosis Rheumatoid arthritis
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摘要

The human papilloma virus (HPV) vaccines were introduced to reduce the incidence of cervical cancer. The bivalent vaccine is effective against HPV-16, -18, -31, -33 and -45 while the quadrivalent vaccine is effective against HPV-16, 18, 31, 6 and 11 types. The immunisation, recommended for adolescent females, has led to high vaccine coverage in many countries. Along with the introduction of the HPV vaccines, several cases of onset or exacerbations of autoimmune diseases following the vaccine shot have been reported in the literature and pharmacovigilance databases, triggering concerns about its safety. This vaccination programme, however, has been introduced in a population that is at high risk for the onset of autoimmune diseases, making it difficult to assess the role of HPV vaccine in these cases and no conclusive studies have been reported thus far. We have thus analysed and reviewed comprehensively all case reports and studies dealing with either the onset of an autoimmune disease in vaccinated subject or the safety in patients with autoimmune diseases to define the role of the HPV vaccines in these diseases and hence its safety. A solid evidence of causal relationship was provided in few cases in the examined studies, and the risk vs. benefit of vaccination is still to be solved. The on-going vigilance for the safety of this vaccine remains thus of paramount importance.

译文

引入人乳头瘤病毒 (HPV) 疫苗以降低宫颈癌的发病率。二价疫苗对 HPV-16 、-18 、-31 、-33 和-45 有效,而四价疫苗对 HPV-16 、 18 、 31 、 6 和 11 种疫苗有效。推荐给青春期女性的免疫接种已经导致许多国家的疫苗覆盖率很高。随着人类乳头瘤病毒疫苗的引入,文献和药物警戒数据库中报道了疫苗注射后自身免疫疾病的发病或恶化的几个案例,引发了对其安全性的担忧。然而,这种疫苗接种计划已经被引入到自身免疫性疾病发病的高风险人群中, 很难评估人类乳头瘤病毒疫苗在这些病例中的作用,迄今为止还没有结论性的研究报告。因此,我们对所有病例报告和研究进行了全面分析和回顾,这些报告和研究涉及接种疫苗的受试者自身免疫性疾病的发病或自身免疫性疾病患者的安全性,以确定人乳头状瘤病毒疫苗的作用。在这些疾病中,因此它是安全的。在调查研究中,很少有案例提供了因果关系的确凿证据,疫苗接种的风险与收益仍有待解决。因此,对这种疫苗安全性的持续警惕仍然至关重要。

Human Papilloma Virus vaccine

肿瘤 HPV疫苗、宫颈癌 治疗方法
概述  :  

宫颈癌是常见的妇科恶性肿瘤,严重威胁女性健康及生命。全球每年约9%的女性新发癌症病例为宫颈癌,其中80%发生在发展中国家。中国每年新发病例约13万例。人乳头瘤病毒(HPV)感染是宫颈癌的主要致病原因,研究表明,高危型HPV持续、慢性感染与宫颈癌的发生密切相关,以HPV16/18型最常见。HPV是环装双链DNA病毒,呈无包膜的二十面体。 至今已发现200多种不同亚型的HPV,约54种可能感染生殖道黏膜,其中15种致癌性HPV可在宫颈癌患者中查到。其中高危型

Human   英 /ˈhjuːmən/   美 /ˈhjuːmən/

释    义   adj. 人的;人类的

               n. 人;人类

同根词   humanism adj. 人文主义的;人道主义的

               humanist adj. 人文主义的;人道主义的

               humanlike adj. 似人类的

               humanly adv. 以人力;像人地;在人力所能及的范围

               humanity n. 人类;人道;仁慈;人文学科

               humanism n. 人道主义

               humanist n. 人道主义者;人类学者,人文学者;人文主义者

               humanization n. 人类化;教化;

例    句   Doctors study the structure of the human body. 医生研究人体构造。

 

Papilloma   英 /ˌpæpɪˈləʊmə/   美 /ˌpæpɪˈloʊmə/

释    义   n. 乳头状瘤,乳突淋瘤

例    句   New research into the body's immune response to the human papilloma virus (HPV) could lead to a vaccine against cervical cancer, a study said. 英国科学家最近进行的一项关于人体对人乳头瘤病毒(HPV)的免疫反应的最新研究可能会导致一种对抗子宫颈癌的疫苗被研制出来。

 

Virus   英 /ˈvaɪrəs/   美 /ˈvaɪrəs/

释    义   n. [病毒] 病毒;恶毒;毒害

               n. (Virus)人名;(西)比鲁斯

同根词   virucidal adj. 杀病毒的

               virulently adv. 恶毒地

例    句   However, we will keep this policy under review as we learn more about the virus and its effects. 然而,因为我们对这一病毒和其影响了解得更多,我们将继续审查这一政策。

 

Vaccine   英 /ˈvæksiːn/   美 /vækˈsiːn/

释    义   n. 疫苗;牛痘苗

               adj. 疫苗的;牛痘的

同根词   vaccination n. 接种疫苗;种痘

               vaccinate n. 被接种牛痘者

               vaccinator n.牛痘接种员;种痘刀

               vaccinate vi.接种疫苗

               vaccinate vt. 给…注射疫苗

例    句   The vaccine was developed, from start to finish, in less than a decade, in record time, and at about one-tenth of the cost usually needed to bring a product through development to the market. 该疫苗的开发,从一开始到完成用了不到十年时间,这是创纪录的,在成本方面是通常情况下一个产品从开发到走向市场所需经费的大约十分之一。

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