摘要

Most children were concomitantly receiving 1 or more heart failure drugs, including angiotensinconverting enzyme inhibitors, diuretics, betablockers, digitalis, and angiotensin II receptor antagonists. The proportion of children taking any of these drugs did not differ by treatment group.Briefly, the ivabradine group was substantially more likely to reach the primary endpoint of a 20% reduction in heart rate than was the placebo group at 12 months. The secondary, echocardiographic endpoints of left ventricular (LV) fractional shortening and LV end-systolic volume at 12 months also improved markedly in the ivabradine group. Another secondary endpoint, quality-of-life scores, improved slightly in the treatment group, but the improvement was not statistically significant. The quality-of-life metric is useful because patient-reported outcomes are increasingly considered to be as important as clinical responses . The trial design and analysis were robust, and the investigators appropriately interpreted the results. This study is a significant addition to the few clinical trials of drugs for treating heart failure in this population.

译文

大多数儿童同时接受一种或多种心力衰竭药物,包括血管紧张素转换酶抑制剂,利尿剂,β受体阻滞剂,洋地黄和血管紧张素II受体拮抗剂。服用这些药物的儿童比例在治疗组之间没有差异。简而言之,在12个月时,伊伐布雷定组比安慰剂组更有可能达到将心率降低20%的主要终点。伊伐布雷定组在12个月时左心室(LV)缩短和左室收缩末期容积的次要超声心动图终点也得到了明显改善。生活质量评分是治疗组中的另一个次要终点,但改善无统计学意义。生活质量指标非常有用,因为越来越多的患者报告的结果与临床反应一样重要。试验设计和分析是可靠的,研究者适当地解释了结果。这项研究是对该人群治疗心力衰竭药物的少数临床试验的重要补充。

Ivabradine with heart failure

重症 心力衰竭 药物
概述  :  

心力衰竭(心衰)是由于各种心脏结构和器质性疾病导致的心室收缩与舒张功能减退、心室充盈压增高所引起的综合征。目前,传统的治疗心衰的标准药物有利尿剂、β受体阻滞剂、肾素-血管紧张素-醛固酮系统拮抗剂等,可改善心衰的临床症状,降低病死率,但心衰发病率和死亡率仍然很高,这意味着急需新的治疗药物和方法。依伐布雷定(ivabradine)作为2012年欧洲心脏病协会治疗心衰指南中的新药,近年来一直在心血管领域受到广泛关注。有报告指出,应用指南中的基础药物治疗后,再合用依伐布雷定能减

ivabradine

释义   伊伐布雷定

例句   I would like to select a few of these, in particular the SHIFT Study which explored the new potential benefits of ivabradine which reduces heart rate.我想特别指出其中几项试验,尤其是SHIFT研究。该研究观察了伊伐布雷定降低心率的潜在益处,这是一个新发现。

 

heart 英 /hɑːt/ 美 /hɑːrt/

释义   n. 心脏;感情;勇气;心形;要点;vt. 鼓励;铭记;vi. 结心;n. (Heart)人名;(英)哈特

例句   His heart is beating violently in her breast.他的心在胸膛里激烈地跳动。

 

failure 英 /ˈfeɪljə(r)/ 美 /ˈfeɪljər/

释义   n. 失败;故障;失败者;破产

例句   The plan suffered a great failure.这项计划失败得很惨。

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