摘要

Progranulin (PGRN) is a cysteine-rich protein that is crucial in diverse biological processes, such as cell proliferation and embryonic development and is known to perform various biological functions, such as protection against vascular disorders and neuronal disorders. PGRN can be subjected to protease-mediated cleavage by enzymes, such as neutrophil elastase to release granulin (GRN). Both PGRN and GRN have biological activities, although often with those opposing functions in immunoreactions. In a mouse model of rheumatoid arthritis, PGRN was found to inhibit inflammation by suppressing the TNF-α-mediated intracellular signaling pathway. Also, PGRN is a neurotrophic factor that promotes cellular survival and stimulates neurite outgrowth in the nervous system. 译Progranulin(PGRN)是一种富含半胱氨酸的蛋白质,在细胞增殖和胚胎发育等多种生物学过程中起着至关重要的作用,并具有多种生物学功能,如对血管疾病和神经元疾病的保护作用。PGRN可以通过蛋白酶介导的酶裂解,如中性粒细胞弹性蛋白酶释放颗粒蛋白(GRN)。PGRN和GRN都具有生物学活性,尽管它们在免疫反应中常常具有相反的功能。在类风湿关节炎小鼠模型中,PGRN通过抑制TNF-α介导的细胞内信号通路抑制炎症反应。此外,PGRN是一种神经营养因子,可促进细胞存活和刺激神经系统的突起生长。



	



	Therefore, PGRN is suggested to be a promising neuroprotection option that helps to improve the neurological functions after ischemia, which is thought to be mostly due to its role in decreasing the expression of inflammatory cytokines and increasing that of anti-inflammatory cytokines. On the other hand, GRN plays a role as a pro-inflammatory factor. It has been reported that A549 and SW-13 cells produce large amounts of IL-8 in response to the addition of recombinant GRN to the culture medium. These findings raise the possibility that PGRN and GRN play a pivotal role in inflammatory responses during the acute phase of brain ischemia. However, the pathophysiological roles of PGRN and GRN, after cerebral ischemia, are not yet fully understood. 译因此,PGRN被认为是一种有助于改善缺血后神经功能的有前途的神经保护药物,其主要作用是降低炎症细胞因子的表达,增加抗炎细胞因子的表达。另一方面,GRN作为促炎症因子发挥作用。据报道,A549和SW-13细胞在培养基中加入重组GRN后产生大量IL-8。这些发现增加了PGRN和GRN在脑缺血急性期炎症反应中发挥关键作用的可能性。然而,PGRN和GRN在脑缺血后的病理生理作用尚不完全清楚。



	



	Therefore, the aim of this study was to obtain further insight into the pathologic roles of PGRN and GRN. In the present study, we used the microsphere-induced cerebral embolism (ME) model in rats. ME induces widespread formation of small emboli and multiple infarct areas in the brain. 译因此,本研究的目的是进一步了解PGRN和GRN的病理作用。本研究采用微球诱导大鼠脑栓塞(ME)模型。ME可导致脑内广泛形成小栓塞和多发梗死区。

译文

Progranulin(PGRN)是一种富含半胱氨酸的蛋白质,在细胞增殖和胚胎发育等多种生物学过程中起着至关重要的作用,并具有多种生物学功能,如对血管疾病和神经元疾病的保护作用。PGRN可以通过蛋白酶介导的酶裂解,如中性粒细胞弹性蛋白酶释放颗粒蛋白(GRN)。PGRN和GRN都具有生物学活性,尽管它们在免疫反应中常常具有相反的功能。在类风湿关节炎小鼠模型中,PGRN通过抑制TNF-α介导的细胞内信号通路抑制炎症反应。此外,PGRN是一种神经营养因子,可促进细胞存活和刺激神经系统的突起生长。

因此,PGRN被认为是一种有助于改善缺血后神经功能的有前途的神经保护药物,其主要作用是降低炎症细胞因子的表达,增加抗炎细胞因子的表达。另一方面,GRN作为促炎症因子发挥作用。据报道,A549和SW-13细胞在培养基中加入重组GRN后产生大量IL-8。这些发现增加了PGRN和GRN在脑缺血急性期炎症反应中发挥关键作用的可能性。然而,PGRN和GRN在脑缺血后的病理生理作用尚不完全清楚。

因此,本研究的目的是进一步了解PGRN和GRN的病理作用。本研究采用微球诱导大鼠脑栓塞(ME)模型。ME可导致脑内广泛形成小栓塞和多发梗死区。

Granulin

内分泌 蛋白 临床研究术语
概述  :  

颗粒蛋白是人类中由GRN基因编码的一种蛋白质。每个颗粒蛋白都从前体颗粒蛋白前体中切出,前体颗粒蛋白长593个氨基酸,蛋白含量为68.5kDa。尽管尚未确定前颗粒蛋白和颗粒蛋白的功能,但两种蛋白形式均与发育,炎症,细胞增殖和蛋白稳态有关。 分子结构 每个单独的颗粒蛋白结构域肽的长度为60个氨基酸。颗粒蛋白肽富含半胱氨酸,每个残基能够形成6个二硫键。二硫键形成一个中心杆状核心,将每个颗粒蛋白肽穿梭成堆叠的β-折叠结构。颗粒蛋白的结

granulin

释    义   n. [生化] 颗粒体蛋白

例    句   Granulin is a protein that in humans is encoded by the GRN gene.颗粒蛋白是人类中由GRN基因编码的蛋白质。

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