摘要

The chemotactic and tumoricidal properties of the pathogenic/free-living amoeba Acanthamoeba castellanii were examined in vivo and in vitro. A. castellanii trophozoites displayed strong positive chemotactic responses to human melanoma (OCM-1) and murine melanoma (D5.1G4) cells. Although the parasites typically invade and destroy the corneal epithelium and stroma, positive chemotactic responses were not detected against extracts of either of these corneal elements. In vitro studies revealed that viable parasites, as well as cell-free parasite lysates, produced swift and extensive cytolysis of a wide variety of tumor cells. The tumoricidal properties of A. castellanii were examined in vivo and revealed that injection of viable parasites or cell-free parasite lysates into progressively growing subcutaneous melanomas resulted in 83% and 53% reductions in the tumor masses compared with untreated controls. The feasibility of utilizing the tumoricidal properties of pathogenic/free-living amoebae and their cell-free products in the treatment of drug-resistant or radioresistant tumors warrants further investigation.

译文

在体内和体外研究了致病性/自由存活的棘阿米巴的趋化性和杀瘤性。A.castellanii 滋养体对人类黑素瘤 (OCM-1) 和小鼠黑素瘤 (D5.1G4) 细胞表现出强烈的阳性趋化反应。尽管寄生虫通常会侵入并破坏角膜上皮和基质,但在这些角膜元素的提取物中没有检测到阳性的趋化反应。体外研究显示,活的寄生虫,以及无细胞的寄生虫裂解物,产生迅速和广泛的各种肿瘤细胞的细胞溶解。A 的抑瘤特性。对 castellanii 进行了体内检查,发现将活寄生虫或无细胞寄生虫裂解物注射到逐渐生长的皮下黑素瘤中,与未经治疗的对照组相比,肿瘤肿块减少了 83% 和 53%。利用致病性/无活性变形虫及其无细胞产物的杀瘤特性治疗耐药或放射抗性肿瘤的可行性值得进一步研究。

Amoeba

消化 寄生虫 临床研究术语
概述  :  

阿米巴原虫主要寄生于结肠内,引起阿米巴痢疾或阿米巴结肠炎。痢疾阿米巴也是根足虫纲中最重要的致病种类,在一定条件下,并可扩延至肝、肺、脑、泌尿生殖系和其他部位,形成溃疡和脓肿。阿米巴原虫病主要是由溶组织内阿米巴引起的一种高发病率、高度致病性的人兽共患寄生虫病。该原虫多寄生于人和动物的肠道和肝脏,较少寄生于肺脏、脑和脾脏等部位,且以滋养体形式侵袭机体,引发阿米巴痢疾或肝脓肿。阿米巴原虫病是一种侵袭性较强的疾病,可在人和动物间自然传播,凡是从粪便中排出阿米巴包囊的人和动物,都可成为感染源。感染该病

Amoeba 英 /ə'miːbə/  美 /ə'miːbə/

释    义   n. [动]阿米巴;变形虫(单细胞生物)

同根词   amoebic  adj. [动]变形虫的,变形虫状的;变形虫引起的

例    句   Sure, it helps to know some history, but a grasp of biology now is even more useful — like how an amoeba reproduces by constantly splitting itself in half. 当然,了解一些历史会有所帮助,但是掌握生物学知识现在更有用的-例如阿米巴虫是如何不断一分为二,分裂繁殖的。

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